Drug Resistance

Baseline Drug Resistance Assays May Help Predict Protease Inhibitor Failure

Published in AIDS Weekly, November 8th, 1999

Baseline resistance to ritonavir or saquinavir, or a combination of both drugs, was associated with a poor antiviral response.

P.R. Harrigan and colleagues performed a study to determine whether baseline drug resistance assays could help to predict treatment failure with the protease inhibitor combination ritonavir-saquinavir ("Baseline HIV Drug Resistance Profile Predicts Response to Ritonavir-Saquinavir Protease Inhibitor Therapy in a Community Setting," AIDS, October 1, 1999;13(14):1863-1871).

The researchers determined baseline HIV-1 drug resistance for 76 consecutive patients who started treatment with the dual protease inhibitor combination...

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Source: AIDS Weekly (1999-11-08)

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