Pharmacokinetics (Animal Studies)

U.S. NCI Researchers Study AIDS Drug Lodenosine

Published in AIDS Weekly, November 8th, 1999

Researchers from the U.S. National Cancer Institute (NCI) have a favorable opinion about an experimental AIDS drug, F-ddA or lodenosine, after completing a study involving three monkeys.

According to this study from the United States government researchers, "2'-beta-Fluoro-2',3'-dideoxyadenosine (F-ddA, lodenosine) is a nucleoside analog that was rationally designed as a more chemically and enzymatically stable anti-AIDS drug than its parent compound 2',3'-dideoxyadenosine or didanosine. Plasma and cerebrospinal fluid (CSF) pharmacokinetics of this compound and its major metabolite, 2'-beta-fluoro-2',3'-dideoxyinosine (F-ddI), were studied in three rhesus monkeys after...

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Source: AIDS Weekly (1999-11-08)

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