Published in AIDS Weekly, November 8th, 1999
Prion diseases are transmissible neurodegenerative disorders of rodents, ruminants, and humans. Prion infections can present without clinical manifestations. B-cell deficiency may be a model for subclinical transmissible spongiform encephalopathy (TSE), since it protects mice from disease upon intraperitoneal administration of scrapie prions. However, a proportion of B-cell-deficient mice accumulate protease-resistant prion protein in their brains, indicated Rico Frigg and colleagues of...
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