Prion Diseases

Subclinical Scrapie Infection Not Influenced by B Cells

Published in AIDS Weekly, November 8th, 1999

by Cathy Clark, Senior Editor -- B lymphocytes and their secreted products do not appear to have a direct effect on subclinical prion infection, recent study findings confirm.

Prion diseases are transmissible neurodegenerative disorders of rodents, ruminants, and humans. Prion infections can present without clinical manifestations. B-cell deficiency may be a model for subclinical transmissible spongiform encephalopathy (TSE), since it protects mice from disease upon intraperitoneal administration of scrapie prions. However, a proportion of B-cell-deficient mice accumulate protease-resistant prion protein in their brains, indicated Rico Frigg and colleagues of...

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Source: AIDS Weekly (1999-11-08)

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