Vector Development
Non-Viral Polycation-Based Vector Delivers to CD4+ Cells
Published in AIDS Weekly, November 22nd, 1999
"CD4- selective targeting of an antibody-polycation-DNA complex was investigated," stated R.L. Puls and colleagues from the University Western Australia ("Gene Transfer and Expression of a Non-Viral Polycation-Based Vector in CD4+ Cells," Gene Therapy, October 1999;6(10):1774-1778).
The researchers synthesized the complex with the anti-CD4 monoclonal antibody B-F5, polylysine(268) (pLL), and either the pGL3 control vector containing the luciferase reporter gene or the...
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Source: AIDS Weekly (1999-11-22)
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