Diagnostics (HIV)

Creatinine Clearance Estimation Tests Not Reliable

Published in AIDS Weekly, November 22nd, 1999

Estimates of creatinine clearance (CrC) do not adequately warn of renal insufficiency (RI) in AIDS patients undergoing antiviral therapy, suggest researchers from Brazil.

Different methods of prediction of CrC have been developed to provide a rapid estimation of renal function and to guide drug dosing adjustments when there is RI. AIDS patients often have their clinical course complicated by the development of RI. Frequently, AIDS patients experience large skeletal muscle mass weight loss that might interfere with the creatinine kinetics and negate the precision of current CrC estimation methods.

"We studied the accuracy of CrC estimates obtained...

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Source: AIDS Weekly (1999-11-22)

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