HIV Gene Therapy
Ribozyme-Expressing Transgenic Spleen Cells Resist HIV-1
Published in AIDS Weekly, November 22nd, 1999
Michael Andang and colleagues from the Karolinska Institute, Sweden, and the University of California, USA, used HIV-1 pseudotype virus to infect mouse primary spleen cells ex vivo with the purpose of studying anti-HIV-1 hairpin ribozyme efficacy in a transgenic mouse model. The results of their study were published in the Proceedings of the National Academy of Sciences ("Dose-Response Resistance to HIV-1/MuLV Pseudotype Virus ex vivo in a Hairpin Ribozyme Transgenic Mouse Model," PNAS, October 26, 1999;96(22):12749-53).
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Source: AIDS Weekly (1999-11-22)
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