Cytomegalovirus

Hypothermia Linked to Gene Expression

Published in AIDS Weekly, December 13th, 1999

Heat shock proteins induced by hyperthermia may play an important role in the viral regulation of monocytic function by cytomegalovirus.

The immediate-early (IE) genes of human cytomegalovirus (CMV) can be expressed in monocytic cells and are known to regulate viral and cellular genes. Reactivation of HIV-1 may be stimulated by a variety of factors including other viruses and inflammatory cytokines.

Researcher G.K. Iwamoto and colleagues examined the role of hyperthermia and CMV in the regulation of HIV-1 and tumor necrosis factor (TNF)-alpha ("Hyperthermia Enhances Cytomegalovirus Regulation of HIV-1 and TNF-alpha Gene Expression," American Journal...

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Source: AIDS Weekly (1999-12-13)

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