Disease Associations (HIV)

Periodontal Attachment Loss Associated with MHC Haplotype

Published in AIDS Weekly, December 13th, 1999

Peridontal attachment loss in HIV infected patients may be genetically influenced, suggests research from Australia.

"Periodontal attachment loss is mediated by overproduction of tumour necrosis factor (TNF) and interleukin (IL)-1, and appears to have a genetic component," stated P. Price and colleagues, Royal Perth Hospital, Australia. "The 8.1 major histocompatibility complex (MHC) ancestral haplotype (HLA-A1,B8,TNFA-308(2),DR3) is associated with elevated TNF production and predisposes carriers to several autoimmune/immunopathological disorders, including rapid progression of HIV disease, but not early onset periodontal disease in healthy individuals. Rather a high...

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Source: AIDS Weekly (1999-12-13)

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