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Immunology (Animal Models)

Model Could Show How Immune System Is Thwarted by HIV, Cancer

Published in AIDS Weekly, December 13th, 1999

Researchers at the Center for Blood Research and Harvard Medical School reported in the November 23, 1999, Proceedings of the National Academy of Sciences the development of an animal model that literally illuminates one of the most dramatic and, until now, obscure events in the body: how the immune system turns immature T cells into specialized killer, or cytotoxic, T cells, capable of seeking out and destroying cells maimed by cancer and infection.

"Now, we have a model that makes it possible to look at a unique and important subset of cells; first to identify it and then analyze it in novel ways," says Ulrich von Andrian, MD, PhD, HMS associate professor of...

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