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Gene Transfer (HIV-1)

Glycoprotein Incorporation Into Retroviral Particles Explored

Published in AIDS Weekly, January 24th, 2000

by Michelle Marble -- Contrary to previous research, glycoproteins with long cytoplasmic C-terminal regions can be incorporated into retroviral particles, report researchers from Germany.

Previous studies have indicated that incorporation of surface glycoprotein into retroviral particles is not a specific process. Data has suggested that many heterologous viral and cellular glycoproteins can be incorporated as long as they do not have long cytoplasmic C-terminal regions. These long regions were presumed to be sterically inhibitory.

Peter Henriksson and colleagues from Forschungsschwerpunkt Angewandte Tumorvirologie, Germany, directly examined this...

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