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AIDS Therapies

Tyrosine Linked Prodrug Improves Nasal Delivery

Published in AIDS Weekly, January 31st, 2000

A tyrosine linked prodrug approach can be used to optimize nasal delivery of zidovudine (AZT), reported researchers from the United States.

"Previous studies have demonstrated that nasal absorption of tyrosine and tyrosine linked model compounds is by a carrier-mediated mechanism," wrote C. Yang and colleagues from the University of Missouri. "The objective of this study is to optimize nasal delivery of AZT via tyrosine linked prodrug approach."

Yang et al. presented their study at the 1999 Annual Meeting of the American Association for Pharmaceutical Scientists, held November 14-18, 1999, in New Orleans, Louisiana.

According to...

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