Published in AIDS Weekly, February 7th, 2000
A. Vacca and colleagues tested the effects of vinblastine (VBL) on endothelial cell functions involved in angiogenesis, namely proliferation, chemotaxis, spreading on fibronectin (FN), secretion of matrix-metalloproteinase-2 (MMP-2) and MMP-9, and morphogenesis on Matrigel were tested in vitro. The researchers studied its effects on angiogenesis in vivo by using the chick embryo chorioallantoic membrane (CAM) model. They reported their study in the journal Blood ("Antiangiogenesis is produced by nontoxic doses of...
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