HIV Dementia

Neurological Disease Possibly Related to Immune Cell Infiltration into Brain

Published in AIDS Weekly, February 7th, 2000

There is some concern that protease inhibitor treatment could leave HIV infected individuals vulnerable to HIV dementia, since these clinically important antiviral drugs are unable to penetrate the brain and stop HIV from replicating there.

However, numerous lines of evidence suggest instead "... that the critical events initiating the development of dementia occur outside the brain," according to Suzanne Gartner, Johns Hopkins University Hospital, Baltimore, Maryland.

As she discussed in a Perspective in the January 28, 2000, issue of Science, studies indicate that HIV neurological disease may be linked to an increase in monocyte (a type...

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Source: AIDS Weekly (2000-02-07)

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