Published in AIDS Weekly, March 6th, 2000
"Live-attenuated SIVs deleted of accessory genes such as nef, vpr, vpx, and upstream region of LTR have been used as vaccine candidates for AIDS in monkeys," said Antimina Puca and colleagues from the Dipartimento di Biochimica e Biotecnologie Mediche, Italy. "This vaccine approach conferred protective immunity against pathogenic SIV; however, it raised serious concerns due to pathogenic mutants which were generated after in vivo replication of the live-attenuated virus vaccine. Hence, additional...
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