Pathogenesis

Differences in TNF-(alpha) Secretion May Impact Disease Course

Published in AIDS Weekly, March 13th, 2000

Differences among HIV-1 variants in the ability to elicit tumor necrosis factor-alpha secretions may have a direct impact on HIV disease course, according to a report from Baltimore's Johns Hopkins University.

HIV-1 infection of human PBMC has been shown to elicit secretion of several different cytokines, TNF-alpha secretion induced by this virus has been of particular interest because it has been associated with the development of HIV-1 dementia and because TNF-alpha increases viral replication by enhancing NF-kappa B interaction with the viral promoter, the HIV-1 long terminal repeat.

"Thus, an autocrine pathway is potentially created in which...

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Source: AIDS Weekly (2000-03-13)

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