Published in AIDS Weekly, March 13th, 2000
HIV-1 infection of human PBMC has been shown to elicit secretion of several different cytokines, TNF-alpha secretion induced by this virus has been of particular interest because it has been associated with the development of HIV-1 dementia and because TNF-alpha increases viral replication by enhancing NF-kappa B interaction with the viral promoter, the HIV-1 long terminal repeat.
"Thus, an autocrine pathway is potentially created in which...
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