HIV Gene Therapy

Long-Term Gene Expression Induced After Vector-Mediated Transduction

Published in AIDS Weekly, March 20th, 2000

Long-term multilineage expression was induced in peripheral blood from a Moloney murine leukemia virus vector after serial transplantation of gene transduced bone marrow cells, researchers from the United States reported.

"Using a mouse bone marrow transplantation model, we evaluated a Moloney murine leukemia virus (MMLV)-based vector encoding two anti-human immunodeficiency virus (HIV) genes for long-term expression in blood cells," wrote T.W. Austin and colleagues, SyStemix Inc., California, USA. "The vector also encoded the human nerve growth factor receptor (NGFR) to serve as a cell-surface marker for in vivo tracking of transduced cells."

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Source: AIDS Weekly (2000-03-20)

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