AIDS Therapies

Resensitization to Zidovudine Reported

Published in AIDS Weekly, March 20th, 2000

Researchers in France reported on the resensitization to zidovudine of HIV patients with previous zidovudine resistance in the Delta Lamivudine Roll-Over Study.

Researcher B. Masquelier and colleagues examined zidovudine resensitization and dual resistance to zidovudine/lamivudine in HIV-1 isolates from nucleoside reverse transcriptase (RT) inhibitor-experienced patients during selective pressure exerted by zidovudine/lamivudine combination therapy.

HIV-1 isolates from 29 patients receiving zidovudine/lamivudine combination therapy in the Delta Roll-Over Study were analyzed at entry and during a one year follow-up period for phenotypic susceptibility...

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Source: AIDS Weekly (2000-03-20)

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