Adverse Drug Effects

Combination Treatment May Precipitate Sensory Neuropathy

Published in AIDS Weekly, April 17th, 2000

Scientists at Johns Hopkins School of Medicine report that a combination of didanosine (ddl), stavudine (d4T), and hydroxyurea may significantly increase the risk of acquiring sensory neuropathy.

"Sensory neuropathy is a common adverse effect of the nucleoside analogue antiretroviral drugs didanosine and stavudine," according to R.D. Moore and other scientists who reported their findings in the journal AIDS.

They performed a comparative study of the incidence of sensory neuropathy using the two drugs in combination with hydroxyurea, alone with hydroxyurea, and in monotherapy.

"Cox proportional hazard regression was used to...

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Source: AIDS Weekly (2000-04-17)

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