Biochemistry

RNA Mediates Protein-Protein Binding in Opportunistic Infection

Published in AIDS Weekly, April 17th, 2000

The HIV-1 Tat and Pur (alpha) protein complex depends on RNA binding to form a good bond. RNA enhances the Pur (alpha) site to make the complex stronger, scientists at CUNY Mt. Sinai School of Medicine report.

This dual protein complex has been recognized as an activator for the JC virus (JCV) late promoter and an enhancer for the replication of JCV DNA replication, according to M.M. Wortman and colleagues.

"JCV is the causative agent of progressive multifocal leukoencephalopathy (PML), an acquired immunodeficiency syndrome (AIDS) opportunistic infection of the brain," the study authors said.

In addition to the role it plays in...

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Source: AIDS Weekly (2000-04-17)

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