Pathogenesis

Major Chemokine Receptor for HIV Type 1 is Modulated by CD28

Published in AIDS Weekly, June 5th, 2000

CD28 has a major influence on the expression of surface CXC chemokine receptor 4 (CXCR4), which is known to be a major cell receptor targeted by the human immunodeficiency virus.

In this study, published in the Journal of Immunology, investigators used anti-CD3 and anti-CD28 monoclonal antibodies (MAbs) to investigate CD28 expression in CD4⁺ T cells. "Anti-CD3 alone induced a progressive down-regulation of surface CXCR4 accompanied by a significant decline in the entry of the HXB2 T-cell line-tropic (X4-tropic) HIV-1 clone in CD4⁺ T cells," P. Secchiero, University of Maryland in Baltimore, and colleagues reported.

They...

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Source: AIDS Weekly (2000-06-05)

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