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HIV Vaccines

DNA Vaccine Reverts Anergy in HIV Infected Patients

Published in AIDS Weekly, July 3rd, 2000

Vaccination with DNA or protein immunogens can revert anergy in HIV infected patients.

"Recent studies have highlighted the importance of T-helper and cytotoxic T lymphocytes (CTL) to contain the early dissemination of HIV-1 in infected individuals," noted Britta Wahren and colleagues from the Karolinska Institute, Sweden. "DNA and glycoprotein immunizations are known to generate immune responses against HIV-1 in animal and human studies. We aimed to assess the efficacy of therapeutic immunization by induction of immune responses in HIV infected humans."

Wahren et al. presented data from their study at the Keystone Symposium, "Novel Biological...

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