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AIDS Therapies

World AIDS Series: Hit HIV-1 Hard, But Only When Necessary

Published in AIDS Weekly, July 3rd, 2000

When should drug therapy to treat HIV-1 infection be initiated'

This is the subject of the fourth in a series of six articles published by The Lancet in the build-up to the World AIDS 2000 Conference in Durban, South Africa, July 9-14.

Patients' activist Mark Harrington and clinician Charles Carpenter discuss data that justify a balanced approach and the feasibility of randomized controlled trials to provide clearer answers about when to start HIV drug treatment.

Current data show that combination antiretroviral therapy for HIV-1 infection benefits people with CD4 cell counts less than 350 cells/(mu)L. Based on currently...

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