Published in AIDS Weekly, August 7th, 2000
"The chemokine receptors CXCR4 and CCR5 are used as coreceptors by the T-tropic X4 and M-tropic R5 HIV-1 strains, respectively, for entering their target cells," reported E. De Clercq from the Rega Institute for Medical Research, Belgium. "Viral entry can be blocked by the natural ligands for CXCR4 (SDF-1(alpha)) and CCR5 (RANTES, MIP-1(alpha), MIP-1(beta), and derivatives thereof).
"Among the chemokines, LD78(beta), an isoform of MIP-1(alpha) (LD78(alpha)), has proved particularly effective in suppressing CCR5-using R5 HIV-1 replication."
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