HIV Vaccines

Adjuvants Help Induce Mucosal Antibody Immune Responses

Published in AIDS Weekly, August 14th, 2000

The combination of interleukin (IL)-12 and cholera toxin subunit B (CTB) help stimulate mucosal antibody responses to a HIV-1 gp120 subunit vaccine, a new study has found.

"Envelope glycoprotein gp120 is located on the outer surface of HIV-1 and is exposed as a target for antibodies during HIV-1 infection," reported Diana I. Bejan and colleagues from Albany Medical College, New York, and the U.S. Department of Defense, Maryland. "In order to stimulate protective antiviral mucosal immunity to HIV-1, we have used the Th1-inducing cytokine, IL-12, alone or in combination with the mucosal adjuvant CTB for intranasal (i.n.) immunization with the gp120 glycoprotein...

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Source: AIDS Weekly (2000-08-14)

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