AIDS Therapies

Association of Protease Inhibitors with Hyperglycemia, Hyperlipidemia, and Lipodystrophy Confirmed

Published in AIDS Weekly, August 28th, 2000

Although researchers in the United States have been able to confirm that protease inhibitors (PI) cause hyperglycemia, hyperlipidemia, and lipodystrophy in HIV infected patients who take these antivirals, they still do not understand the mechanisms behind the complications.

"Although HIV related morbidity and mortality rates in patients with advanced HIV infection who are treated with combination antiretroviral drugs have declined, significant metabolic adverse effects associated with these regimens have been increasingly recognized," wrote S. Tsiodras and colleagues, Harvard University, Massachusetts. "However, since data from patients studied before and after...

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Source: AIDS Weekly (2000-08-28)

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