Published in AIDS Weekly, September 4th, 2000
"Progressive subcutaneous fat wasting, fat accumulation, dyslipidemia, and insulin resistance in HIV infected patients on antiretroviral therapy have been attributed to the long-term toxicity of HIV protease inhibitors (PI)," stated S.A. Mallal and colleagues, Royal Perth Hospital, Australia. "More recently, fat wasting has been observed in patients who have never taken a PI, implicating an independent effect of nucleoside analogue reverse transcriptase inhibitor (NRTI) therapy."
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