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Cytomegalovirus Retinitis

Intraocular Sustained-Release Ganciclovir Implant Safe and Effective

Published in AIDS Weekly, September 11th, 2000

Researchers in Brazil reported that intraocular sustained-relase ganciclovir (GCV) implants are safe and therapeutically effective against cytomegalovirus (CMV) retinitis in AIDS patients.

Implants were placed in 39 nines of 26 patients. After an average follow-up time of 3.7 months, C. Muccioli and colleagues, Sao Paulo, Brazil, found that all the eyes had been healed of retinitis. This was determined by clinical improvement as evaluated by indirect binocular ophthalmoscopy and retinography.

The CMV retinitis resolved within four to six weeks in all of the treated patients. Clinical regression was obvious from the third week, reported Muccioli...

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