Published in AIDS Weekly, September 18th, 2000
"The potential contribution of a plasmid DNA construct to vaccine-elicited protective immunity was explored in the SIV/macaque model of AIDS," wrote M.A. Egan and colleagues, Wyeth Lederle Vaccines & Pediatrics, New York. "Making use of soluble major histocompatibility class I/peptide tetramers and peptide-specific killing assays to monitor CD8+ T-lymphocyte responses to a dominant SIV Gag epitope in genetically selected rhesus monkeys, a codon-optimized SIV gag DNA vaccine...
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