Vector Development
Infectious HIV-1 Derived Vector Shows Promise for Gene Therapy
Published in AIDS Weekly, September 25th, 2000
"Lentiviral vectors pseudotyped with the envelope glycoproteins (Env) of amphotropic murine leukemia virus (MLV) and the G protein of vesicular stomatitis virus VSV-G) have been successfully used in recent preclinical gene therapy studies," wrote J. Stitz and colleagues, Paul Ehrlich Institute. "We report here the generation of infectious HIV-1 derived vector particles pseudotyped with the Env of the molecular clone 10A1 of MLV and with chimeric envelope glycoprotein variants derived from gibbon ape leukemia virus (GaLV) and MLV."
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Source: AIDS Weekly (2000-09-25)
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