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Cachexia

Study Appears to Show Why Muscle Decays Mysteriously in Cancer, AIDS, Other Illnesses

Published in AIDS Weekly, October 16th, 2000

University of North Carolina at Chapel Hill scientists believe they have discovered a major reason why muscles often decay in patients with cancer, AIDS, late-stage heart disease, severe burns, and numerous chronic diseases.

Their research focuses on cachexia, an important syndrome they say doctors know well but which is largely unfamiliar to lay people, and could lead to an effective treatment for the condition.

Cachexia, which kills an estimated one-third of cancer patients, results from activation of a factor known as NF-kappa B, the new experiments show. NF-kappa B, a natural substance that attaches to DNA inside cell nuclei and turns genes...

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