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HIV Immunotherapy

HIV-1 Envelope-Specific Lymphocytes Stimulated by Semi-Allogeneic Cell Hybrids

Published in AIDS Weekly, October 30th, 2000

According to a study from the United States, semi-allogeneic cell hybrids stimulated HIV-1 envelope-specific cytotoxic T lymphocytes (CTL) in vitro.

"The present study was designed to determine whether the human leukocyte antigen (HLA) allogeneic T helper response stimulated by semi-allogeneic cell lines could be used as an in vitro model of immune-based therapy to stimulate HIV specific CTL," stated E. Grene and colleagues, U.S. National Cancer Institute, Maryland. "Semi-allogeneic cell hybrids were obtained by the fusion of peripheral blood mononuclear cells from HIV infected patients with the allogeneic beta 2-microglobulin-deficient FO1-12 melanoma cell...

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