AIDS Dementia

New HIV Receptor May Offer Insight

Published in AIDS Weekly, December 25th, 2000

An international group headed by researchers from Harvard Medical School has identified an important receptor that HIV-1 may use to target and infect human cells, especially those in the nervous system.

They have also found a protein that may stop it.

They reported their results in the December 2000 issue of the Journal of Virology.

In addition to the already known CCR5 and CXCR4 receptors, it also appears that HIV-1 can bind to and use another receptor, known as APJ, to enter and infect human cells. This receptor is commonly found in the central nervous system and several brain viruses are known to use APJ as a receptor,...

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Source: AIDS Weekly (2000-12-25)

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