Pathogenesis

Protein May Assist HIV-1 Host-Cell Development

Published in AIDS Weekly, January 29th, 2001

The high mobility protein HMG-D interacts with RNA from HIV-1, and may be partially responsible for mediating its replication within host cells, researchers in France suggest.

"The high mobility group protein HMG-D is known to bind preferentially to DNA of irregular structures with little or no sequence specificity," C. Bailly and colleagues at the Institut National de la Sante et de la Recherche Medicale (INSERM) explained in the journal FEBS Letters. "Upon binding to DNA, this HMG-box protein widens the minor groove of the double helix and induces a significant bending of the helix."

Bailly et al. performed in vitro several experiments...

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Source: AIDS Weekly (2001-01-29)

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