Pediatrics

Uninfected Children of HIV Positive Mothers Still Suffer from Impaired Immune Systems

Published in AIDS Weekly, January 29th, 2001

Uninfected children of HIV positive mothers - so-called "seroreverters" - still display persistent immune system abnormalities years after birth, researchers report.

"Cell-mediated immunity and T-lymphocyte maturation are impaired in HIV infected children," explained M. Clerici and colleagues at the University of Milan in Italy. "These abnormalities would be detected in HIV uninfected offspring of HIV women...if HIV or its soluble proteins could cross the placental barrier."

To determine if this is indeed the case, Clerici et al. performed immunophenotypic analyses of 34 healthy, HIV negative newborns, 20 of whom were born to HIV positive...

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Source: AIDS Weekly (2001-01-29)

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