Drug Development

Actinomycin D Selects for DNA Hairpin Loop

Published in AIDS Weekly, February 5th, 2001

- by Michael Greer, staff medical writer -- Researchers in the United States have shown that the selective binding ability of the antibiotic actinomycin D, which underlies its potential as an anti-HIV therapy among other things, relies on the hairpin loop structure of target DNA.

"Our recent work has indicated that the potent antibiotic and antitumor agent actinomycin D has the ability to selectively bind and stabilize single-stranded DNA that is capable of adopting a hairpin conformation," R.M. Wadkins and colleagues at Johns Hopkins University explained in the Archives of Biochemistry and Biophysics. "This mechanism of DNA binding has been implicated in the...

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Source: AIDS Weekly (2001-02-05)

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