Disease Resistance

Peptide's Protective Mechanism Against HIV Revealed

Published in AIDS Weekly, February 19th, 2001

by Michael Greer, staff medical writer -- Biochemists in France have elucidated the mechanisms by which the peptide SPC3 is able to protect against cellular invasion by some HIV strains.

"SPC3 is a multibranched peptide containing eight identical GPGRAF motifs which are derived from the human immunodeficiency virus (HIV)-1 gp120 V3 loop consensus sequence," J.M. Sabatier and colleagues at the Centre National de la Recherche Scientifique explained in the Journal of Peptide Research. "This molecule was reported to prevent the infection of CD4⁺ cells by various HIV-1 and HIV-2 strains ... However, the molecular mode of action of SPC3 remains...

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Source: AIDS Weekly (2001-02-19)

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