Pathogenesis

Gag/Gag-Pol Ratio Crucial for Viral Infectivity

Published in AIDS Weekly, February 19th, 2001

by Michael Greer, staff medical writer -- Variations in the relative expression levels of the HIV-1 protein Gag and its precursor, Gag-Pol, can dramatically affect the levels of viral stability and infectivity, according to immunologists in Australia.

"Production of the human immunodeficiency virus type 1 (HIV-1) Gag-Pol precursor protein results from a -1 ribosomal frameshifting event," Johnson Mak and colleagues at the Macfarlane Burnet Centre for Medical Research explained in the online edition of the Journal of Virology. "In infected cells, this generates Gag and Gag-Pol in a ratio that is estimated to be 20:1, a ratio that is conserved among...

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Source: AIDS Weekly (2001-02-19)

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