Immunology
Interleukin-10 Has Opposite Effects On Dendritic Cells And Macrophages
Published in AIDS Weekly, March 26th, 2001
Petronela Ancuta and colleagues studied IL-10's effect on replication of the X4 HIV strain by monocyte-derived macrophages and dendritic cells, and on these cells' ability to infect CD4+ T lymphocytes. Surprisingly, they found that while the limited replicative ability of dendritic cells is augmented by the presence of IL-10, exposure to the cytokine shuts down macrophage viral replication.
IL-10 actually affected both types of cells in the same way, Ancuta...
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Source: AIDS Weekly (2001-03-26)
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