AIDS-Related Dementia
Opioids Can Worsen Tat-Induced Damage
Published in AIDS Weekly, April 9th, 2001
"[HIV] infection selectively targets the striatum, a region rich in opioid receptor-expressing neural cells, resulting in gliosis and neuronal losses," explained J.A. Gurwell and colleagues at the University of Kentucky, who noted that "opioids can be neuroprotective or can promote neurodegeneration."
Gurwell et al. found strong evidence showing that in the presence of the Tat protein, opioids fall into the latter category.
At doses as low as 10 nM,...
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Source: AIDS Weekly (2001-04-09)
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