HIV Pathogenesis

Interleukin-2 Can Reverse Defective T-Cell Effector Function

Published in AIDS Weekly, April 23rd, 2001

by Michael Greer, staff medical writer - Functioning T cells can become impotent against HIV infected cells despite functioning antigen recognition, a defect that can be reversed by treatment with a T-cell stimulating cytokine, researchers in Canada say.

"A vigorous expansion of antigen-specific CD8⁺ T cells lacking apparent effector function was observed in a rhesus macaque acutely infected with the simian immunodeficiency virus (SIV)," Y.L. Xiong and colleagues wrote in the Journal of Virology.

Xiong et al. found that this immune deficiency could be corrected by treatment with interleukin-2, a cytokine that promotes T-cell...

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Source: AIDS Weekly (2001-04-23)

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