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AIDS Therapies

Once-Daily Dosing Holds Concentrations But With Side Effects

Published in AIDS Weekly, May 7th, 2001

Roche announced April 18, 2001, preliminary clinical data from four ongoing studies examining tolerability and antiviral activity with once-daily dosing of its protease inhibitor FortovaseR (saquinavir) plus a mini-dose of another protease inhibitor, ritonavir.

These data were presented at the International Workshop on HIV Clinical Pharmacology in Noordwijk, The Netherlands, April 2-4, 2001.

"These studies with once-daily Fortovase plus ritonavir are in line with recent changes in U.S. HIV treatment guidelines, which supported the use of such boosted protease inhibitor regimens as a means of possibly simplifying dosing regimens and thus...

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