HIV Virology

Sequences Inhibiting Surface Env Expression Found

Published in AIDS Weekly, May 21st, 2001

by Michael Greer, senior medical writer - Researchers in Germany have discovered a pair of motifs in HIV's cytoplasmic tail that suppress surface expression of the Env protein.

"Only a small fraction of [Env glycoprotein] gp160 appears to be ... transported to the cell surface, which makes it difficult to identify negative sequence elements regulating steady-state surface expression of Env at the post-ER [endoplasmic reticulum] level," Jurgen Haas and colleagues explained in the Journal of Virology.

Haas and colleagues devised a method to isolate Env-regulating motifs, which yielded two sequences shown to inhibit surface Env expression, they...

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Source: AIDS Weekly (2001-05-21)

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