Pharmacogenetics

Proteins In African HIV Strains Interact Differently With Drugs

Published in AIDS Weekly, June 4th, 2001

Naturally-occurring genetic variations in HIV-A and HIV-C, the two subtypes of HIV prevalent in Africa, make it harder for inhibitory drugs to bind to the protease, a key protein involved in viral maturation, according to a new report by biologists in The Krieger School of Arts and Sciences of The Johns Hopkins University.

Ernesto Freire, the Henry A. Walters professor of biology, emphasized that the new findings, published in The Proceedings of the National Academy of Sciences, are based on in-vitro tests of basic biochemical properties, and therefore cannot be used to assess the effectiveness of inhibitor drugs in patient treatments.

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Source: AIDS Weekly (2001-06-04)

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