Pathogenesis
Mucosal Immunoglobin A Blocks Epithelial HIV Penetration
Published in AIDS Weekly, June 4th, 2001
"As one of the initial mucosal transmission pathways of HIV ... epithelial cells translocate HIV-1 from apical to basolateral surface by nondegradative transcytosis," explained Annette Alfsen and colleagues at the Cochin Institute for Molecular Genetics.
Mucosal IgA is able to abort this process, possibly providing a new therapeutic target for preventing HIV infection, Alfsen and coworkers report.
For transcytosis to occur, the HIV envelope glycoprotein gp41 must be able to bind to...
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Source: AIDS Weekly (2001-06-04)
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