Virology

Altering HIV Mutation Patterns May Prevent Drug Resistance

Published in AIDS Weekly, June 18th, 2001

by Michael Greer, senior medical writer - Researchers in Belgium have altered the mutation patterns of HIV in some infected cultures, possibly paving the way for techniques to prevent the development of drug-resistant strains of the virus.

"The adenine nucleotide bias together with the poor fidelity of HIV 1 reverse transcriptase markedly enhances the genetic variation of HIV and may be responsible for the rapid emergence of drug-resistant HIV 1 strains," explained Jan Balzarini and colleagues at Katholieke Universiteit Leuven.

Balzarini and colleagues showed that it was possible to change the nucleotide bias of HIV, which may slow or halt the...

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Source: AIDS Weekly (2001-06-18)

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