HIV Neuropathy

High Quinolinic Acid Cerebrospinal Fluid Levels Linked To Brain Atrophy

Published in AIDS Weekly, July 23rd, 2001

by Michael Greer, senior medical writer - Elevated levels of quinolinic acid in the cerebrospinal fluid (CSF) of HIV patients are a marker of cerebral damage, researchers in California report.

"Neuronal injury, dendritic loss and brain atrophy are frequent complications of infection with human immunodeficiency virus (HIV) type 1," explained M.P. Heyes and colleagues at the U.S. National Institute of Mental Health, Bethesda, Maryland, and the University of California, San Diego.

Hypothesizing that cellular release of quinolinic acid may contribute to HIV related neurodegeneration, Heyes and coworkers found that high CSF concentrations of the...

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Source: AIDS Weekly (2001-07-23)

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