AIDS Therapies

Indinavir Reduces Skeletal Muscle Glucose Transport

Published in AIDS Weekly, July 23rd, 2001

by Michael Greer, senior medical writer - The HIV protease inhibitor indinavir contributes to the lipodystrophy experienced by many patients by impairing glucose transport in skeletal muscles, researchers in Missouri report.

"In many patients with human immunodeficiency virus (HIV) treated with HIV protease inhibitors, a complication develops that resembles abdominal obesity syndrome, with insulin resistance and glucose intolerance that, in some cases, progresses to diabetes," explained Lorraine A. Nolte and colleagues at Washington University.

Nolte and coworkers reported that indinavir interferes with muscle glucose transport but not through the...

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Source: AIDS Weekly (2001-07-23)

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