Published in AIDS Weekly, August 13th, 2001
"The multidrug transporters P-glycoprotein (P-gp) and MRP1 are functionally expressed in several subclasses of lymphocytes," explained Kevin Jones and colleagues at the University of Liverpool in the United Kingdom and the Bill Walsh Cancer Research Laboratories in St. Leonards, Australia. "HIV 1 protease inhibitors interact with both; consequently the transporters could reduce the local concentration of HIV 1 protease inhibitors and, thus, influence the selection of...
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