AIDS Therapies

Multidrug Transporters Can Reduce Protease Inhibitor Levels

Published in AIDS Weekly, August 13th, 2001

by Michael Greer, senior medical writer - Proteins commonly expressed by some blood cells may increase the risk of developing drug-resistant strains of HIV, researchers in the U.K. and Australia report.

"The multidrug transporters P-glycoprotein (P-gp) and MRP1 are functionally expressed in several subclasses of lymphocytes," explained Kevin Jones and colleagues at the University of Liverpool in the United Kingdom and the Bill Walsh Cancer Research Laboratories in St. Leonards, Australia. "HIV 1 protease inhibitors interact with both; consequently the transporters could reduce the local concentration of HIV 1 protease inhibitors and, thus, influence the selection of...

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Source: AIDS Weekly (2001-08-13)

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