HIV Dementia

Signaling Pathway Blockade May Prevent gp120-Induced Neurological Damage

Published in AIDS Weekly, September 17th, 2001

by Michael Greer, senior medical writer - Researchers say that shutting down part of the mitogen-activated protein kinase (MAPK) signaling pathway might help prevent HIV related neurological damage.

"It has been previously shown that the HIV-1 envelope glycoprotein 120 (gp120) activates cell signaling by CXCR4, independently of CD4, according to Francisco Veas and colleagues at France's National Center for Scientific Research, National Institute for Medical Research (INSERM U454), and the University of Montpellier II; the Armand Frappier Institute in Montreal, and Belgium's Institute for Human and Nuclear Biology Research.

Veas and team isolated the...

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Source: AIDS Weekly (2001-09-17)

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