HIV Vaccine

Gag Optimization Improves Immunogenicity

Published in AIDS Weekly, November 12th, 2001

by Michael Greer, senior medical writer - Researchers in Germany have improved the effectiveness of an HIV vaccine based on viral genetic material.

"We have analyzed the influence of codon usage modifications on the expression levels and immunogenicity of DNA vaccines encoding the human immunodeficiency virus type 1 (HIV-1) group-specific antigen (Gag)," explained Ralf Wagner and colleagues at the University of Regensburg's Institute of Molecular Microbiology and the University of Ulm Institute of Medical Microbiology and Immunology.

Improving the efficiency of the gene sequences coding for Gag enhanced the immunogenicity of these vaccines, Wagner...

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Source: AIDS Weekly (2001-11-12)

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